Clues to immune tolerance: the monogenic autoimmune syndromes
نویسندگان
چکیده
منابع مشابه
Monogenic immune dysregulation syndromes
Introduction Human autoimmune diseases are a major health issue, affecting up to approximately 10% of the population (1). Common human autoimmune diseases are complex disorders that arise from the interactions between polygenic risk factors and environmental factors (2). Intensive investigation of autoimmune disease genetics has the potential to offer an unbiased view of the underlying etiologi...
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Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to unraveling how autoimmunity occurs is to study monogenic diseases, for which a single gene defect is responsible. Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of...
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متن کاملmonogenic auto-inflammatory syndromes: a review of the literature
auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive t cells, and an inborn error of innate immunity. a narrative literature review was carried out of studies related to auto-inflammatory syndromes ...
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We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here, we have demonstrated that HA is critical for the pathogenesis of autoimmune diabetes. Using the DO11.10xRIPmOVA mouse model of T1D, we determined...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2010
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2010.05818.x